A Dynamic Immune Response Shapes COVID-19 Progression.

A Dynamic Immune Response Shapes COVID-19 Progression.

The inflammatory response to SARS-coronavirus-2 (SARS-CoV-2) infection is thought to underpin COVID–19 pathogenesis. We conducted daily transcriptomic profiling of three COVID–19 cases and found that the early immune response in COVID–19 patients is highly dynamic. Patient throat swabs were tested daily for SARS-CoV-2, with the virus persisting for 3 to 4 weeks in all three patients. Cytokine analyses of whole blood …

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